The EPI-BRAIN Initiative is a global data ecosystem that supports data science innovation for outbreak preparedness and response. EPI-BRAIN will enable greater exchange of data, analytics, and methodologies between countries, researchers, non-governmental, and private sector entities. EPI-BRAIN will inform strategies and decision making for outbreak preparedness and response globally. This workshop will engage participants in discussions on some of the core features of EPI-BRAIN: A global data eco-system – promoting greater access to data analysis and insights for outbreaks preparedness and response A curation of practical and impactful use cases – solving problems using improved data science Global partnerships between countries, academia, non-governmental entities, and private sectors entities Data governance covering sharing and use of data